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Globally harmonized system of classification and labelling of chemicals (GHS) - fifth revised edition

image of Globally harmonized system of classification and labelling of chemicals (GHS) - fifth revised edition
The Globally Harmonized System of Classification and Labelling of Chemicals (GHS) addresses classification and labelling of chemicals by types of hazards. It provides the basis for worldwide harmonization of rules and regulations on chemicals and aims at enhancing the protection of human health and the environment during their handling, transport and use by ensuring that the information about their physical, health and environmental hazards is available. The fifth revised edition includes, inter alia, a new test method for oxidizing solids, new miscellaneous changes to further clarify the criteria for the hazard classes skin corrosion/irritation, severe eye damage/irritation and aerosols; revised and simplified classification and labelling summary tables; new codes for pictograms and revised and further rationalized precautionary statements.

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Reproductive toxicity

Reproductive toxicity includes adverse effects on sexual function and fertility in adult males and females, as well as developmental toxicity in the offspring. The definitions presented below are adapted from those agreed as working definitions in IPCS/EHC Document N°225 Principles for evaluating health risks to reproduction associated with exposure to chemicals. For classification purposes, the known induction of genetically based inheritable effects in the offspring is addressed in Germ cell mutagenicity (Chapter 3.5), since in the present classification system it is considered more appropriate to address such effects under the separate hazard class of germ cell mutagenicity.

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